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Our goal is to understand how the brain integrates sensory feedback to control autonomic responses that maintain cardio-respiratory homeostasis. We are also interested in the cross-talk between cardiorespiratory function and affective state. To address these issues, we combine use a systems neuroscience approach such as optogenetics, electrophysiology, and calcium imaging, RNA sequencing and rodent genetics together with surgical manipulations and pharmacology. Through the use of these approaches, we aim to identify the cell types and network interactions that regulate breathing and cardiovascular function, and characterize how changes in the function lead to cardiovascular disease and affective disorders.